A chemical reaction in which the reactant and product chemical species are chemically identical but have different isotopic composition. In such a reaction the isotope distribution tends towards equilibrium (as expressed by fractionation factors) as a result of transfers of isotopically different atoms or groups. For example:
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Sources:
PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1132 (https://doi.org/10.1351/pac199466051077)
PAC, 1994, 66, 2513. 'Nomenclature for radioanalytical chemistry (IUPAC Recommendations 1994)' on page 2521 (https://doi.org/10.1351/pac199466122513)