An analytical method in which a reactant is injected into a calorimetric vessel containing another @R05190@. The @E02141@ change of the ensuing reaction is measured and directly related to the amount of the limiting @R05190@ (usually the analyte). If the experiment determines information other than amounts of analytes, an acceptable synonym is @B00614@. Other terms which have been used in the literature but are not recommended include the @C01233@ and the @D01774@.