chronic

antonym: acute
https://doi.org/10.1351/goldbook.16231
Long-term (in relation to exposure or effect).
Notes:
  1. In experimental toxicology, chronic refers to mammalian studies lasting considerably more than 90 days or to studies occupying a large part of the lifetime of an organism.
  2. In clinical medicine, long-established or long-lasting.
Source:
PAC, 2007, 79, 1583. (Explanatory dictionary of key terms in toxicology (IUPAC Recommendations 2007)) on page 1595 [Terms] [Paper]