{"term":{"id":"15859","title":"linearised multistage model","longtitle":"IUPAC Gold Book - linearised multistage model","doi":"10.1351\/goldbook.15859","code":"15859","status":"current","definitions":[{"id":1,"text":"Sequence of steps in which (a) a multistage model is fitted to tumor incidence data; (b) the maximum linear term consistent with the data is calculated; (c) the low-dose slope of the dose–response function is equated to the coefficient of the maximum linear term; and (d) the resulting slope is then equated to the upper bound of potency.","links":[{"term":"multistage model","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/15903"}],"sources":["PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1251 (https:\/\/doi.org\/10.1351\/pac200779071153)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/15859\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/15859\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/15859\/plain"},"citation":"Citation: 'linearised multistage model' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.15859","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-31T00:23:21+00:00"}}