14421 IUPAC Gold Book - acute 10.1351/goldbook.14421 14421 current antonym: chronic 1 Of short duration, in relation to exposure or effect; the effect usually shows a rapid onset. Note 1: In regulatory toxicology, "acute" refers to studies where dosing is either single or limited to one day although the total study duration may extend to two weeks to permit appearance of toxicity in susceptible organ systems. Note 2: In aquatic ecotoxicology, exposure of the test organisms is typically continuous and of four days or less. In clinical medicine, sudden and severe, having a rapid onset. chronic https://goldbook.iupac.org//terms/view/14524 PAC, 2009, 81, 829. 'Glossary of terms used in ecotoxicology (IUPAC Recommendations 2009)' on page 834 (https://doi.org/10.1351/PAC-REC-08-07-09) https://goldbook.iupac.org/terms/view/14421/html https://goldbook.iupac.org/terms/view/14421/json https://goldbook.iupac.org/terms/view/14421/plain Citation: 'acute' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.14421 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-04-20T19:53:26+00:00