Title: macromolecular prodrug
Long Title: IUPAC Gold Book - macromolecular prodrug
DOI: 10.1351/goldbook.13937
Status: current

Definition
Prodrug in which the temporary chemical entity is a macromolecule.

Note
In this particular case of prodrug, the macromolecule carries several drug molecules generally. These molecules are linked to the carrier through cleavable bonds.

Related Term
- Prodrug: https://goldbook.iupac.org//terms/view/13943

Source
- PAC, 2012, 84, 377. 'Terminology for biorelated polymers and applications (IUPAC Recommendations 2012)' on page 400 (https://doi.org/10.1351/PAC-REC-10-12-04)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13937/html
- json: https://goldbook.iupac.org/terms/view/13937/json
- xml: https://goldbook.iupac.org/terms/view/13937/xml

Citation: Citation: 'macromolecular prodrug' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13937
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Accessed: 2026-06-04T17:51:18+00:00