Title: foreign body reaction
Long Title: IUPAC Gold Book - foreign body reaction
DOI: 10.1351/goldbook.13932
Status: current

Definition
Cellular response of the inflammatory and wound healing processes following introduction of a foreign object in a human or animal body.

Notes
1) The foreign object can be a medical device, a prosthesis, a particle or any compound introduced accidentally.
2) The foreign body reaction results in more or less intense events such as fibrous tissue formation, macrophage activation, giant cells formation, etc.

Related Term
- prosthesis: https://goldbook.iupac.org//terms/view/13944

Source
- PAC, 2012, 84, 377. 'Terminology for biorelated polymers and applications (IUPAC Recommendations 2012)' on page 400 (https://doi.org/10.1351/PAC-REC-10-12-04)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13932/html
- json: https://goldbook.iupac.org/terms/view/13932/json
- xml: https://goldbook.iupac.org/terms/view/13932/xml

Citation: Citation: 'foreign body reaction' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13932
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Accessed: 2026-06-04T13:20:48+00:00