Title: variable gene
Long Title: IUPAC Gold Book - variable gene
DOI: 10.1351/goldbook.13772
Status: current

Definition
Gene, segment(s) of which rearrange together with diversity (D) gene and joining (J) gene segments in order to encode the variable (V) region amino acid sequences of immunoglobulins (Ig) and T-cell receptors (TCRs).

Related Terms
- T-cell receptors (TCRs): https://goldbook.iupac.org//terms/view/13714
- diversity (D) gene: https://goldbook.iupac.org//terms/view/13098
- joining (J) gene: https://goldbook.iupac.org//terms/view/13354
- variable (V) region: https://goldbook.iupac.org//terms/view/13773

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1258 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13772/html
- json: https://goldbook.iupac.org/terms/view/13772/json
- xml: https://goldbook.iupac.org/terms/view/13772/xml

Citation: Citation: 'variable gene' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13772
License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.
Collection: If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .
Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-07-14T02:54:41+00:00