Title: systemic sclerosis
Long Title: IUPAC Gold Book - systemic sclerosis
DOI: 10.1351/goldbook.13711
Status: current

Definition
Fibrosing disease of unclear etiology that affects multiple organ systems.

Notes
1) The skin ("scleroderma") and blood vessels (arteries, small vessels) are most commonly affected, but involvement of the lungs and gastrointestinal tract (esophagus) may also be observed.
2) Anticentromere antibodies (ACA) as well as autoantibodies against DNA topoisomerase I (scl-70) and various nucleolar antigens are diagnostic and prognostic markers and are often detectable years before disease manifestation. They are also detectable in quartz dust-exposed individuals.

Related Terms
- autoantibodies: https://goldbook.iupac.org//terms/view/12913
- scleroderma: https://goldbook.iupac.org//terms/view/13660

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1249 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13711/html
- json: https://goldbook.iupac.org/terms/view/13711/json
- xml: https://goldbook.iupac.org/terms/view/13711/xml

Citation: Citation: 'systemic sclerosis' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13711
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Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-07-12T17:13:45+00:00