Title: rheumatoid factor
Long Title: IUPAC Gold Book - rheumatoid factor
DOI: 10.1351/goldbook.13652
Status: current

Definition
Immunoglobulins IgM, IgG, and IgA autoantibodies to the Fc region of IgG.

Note
Although detectable in various diseases, rheumatoid factor is used as a classification criterion of rheumatoid arthritis (RA).

Related Terms
- Fc region: https://goldbook.iupac.org//terms/view/13137
- IgA: https://goldbook.iupac.org//terms/view/13286
- IgG: https://goldbook.iupac.org//terms/view/13292
- Immunoglobulins IgM: https://goldbook.iupac.org//terms/view/13293
- autoantibodies: https://goldbook.iupac.org//terms/view/13497
- rheumatoid arthritis (RA): https://goldbook.iupac.org//terms/view/13651

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1241 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13652/html
- json: https://goldbook.iupac.org/terms/view/13652/json
- xml: https://goldbook.iupac.org/terms/view/13652/xml

Citation: Citation: 'rheumatoid factor' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13652
License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.
Collection: If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .
Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-07-14T05:52:55+00:00