Title: reverse immunology
Long Title: IUPAC Gold Book - reverse immunology
DOI: 10.1351/goldbook.13648
Status: current

Definition
High-throughput procedure where information on potential immunogenic tumor proteins is gained from the amino acid sequences of gene products specifically expressed by the tumor, followed by predicted fitting of putative antigenic peptides to a peptide-binding groove, and finally experimental verification.

Related Terms
- antigenic: https://goldbook.iupac.org//terms/view/12885
- peptide-binding groove: https://goldbook.iupac.org//terms/view/13548

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1240 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13648/html
- json: https://goldbook.iupac.org/terms/view/13648/json
- xml: https://goldbook.iupac.org/terms/view/13648/xml

Citation: Citation: 'reverse immunology' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13648
License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.
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Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-07-14T13:12:19+00:00