{"term":{"id":"13612","title":"properdin","longtitle":"IUPAC Gold Book - properdin","doi":"10.1351\/goldbook.13612","code":"13612","status":"current","definitions":[{"id":1,"text":"Relatively heat-labile, normal serum protein (a euglobulin) that, in the presence of complement component C3 and magnesium ions, is involved in the alternative pathway of complement activation, and acts nonspecifically against Gram-negative bacteria and viruses and may contribute to the lysis of erythrocytes.","notes":{"1":"It migrates as a β3-globulin and, although not an antibody, may act in conjunction with complement-fixing antibody."},"links":[{"term":"alternative pathway of complement activation","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/12866"},{"term":"erythrocytes","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/13127"},{"term":"euglobulin","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/13130"}],"sources":["PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1236 (https:\/\/doi.org\/10.1351\/PAC-REC-11-06-03)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/13612\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/13612\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/13612\/plain"},"citation":"Citation: 'properdin' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.13612","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-07-24T00:57:41+00:00"}}