Title: nucleotide-binding oligomerization domain-containing protein 1, 2
Long Title: IUPAC Gold Book - nucleotide-binding oligomerization domain-containing protein 1, 2
DOI: 10.1351/goldbook.13519
Status: current

Definition
Members of a family of human intracellular proteins involved in the detection of invasive bacteria and activation of the $\ce{NF\kappa B}$ transcription factor pathway.

Note
In epithelial cells, NOD1 is essential for sensing intracellular Gram-negative bacteria through a tripeptide motif in the bacterial peptidoglycan.

Related Term
- NFκB: https://goldbook.iupac.org//terms/view/13518

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1222 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13519/html
- json: https://goldbook.iupac.org/terms/view/13519/json
- xml: https://goldbook.iupac.org/terms/view/13519/xml

Citation: Citation: 'nucleotide-binding oligomerization domain-containing protein 1, 2' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13519
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Accessed: 2026-07-29T19:53:07+00:00