{"term":{"id":"13519","title":"nucleotide-binding oligomerization domain-containing protein 1, 2","longtitle":"IUPAC Gold Book - nucleotide-binding oligomerization domain-containing protein 1, 2","doi":"10.1351\/goldbook.13519","code":"13519","status":"current","initialism":"<em>initialisms<\/em>: NOD1, NOD2","definitions":[{"id":1,"text":"Members of a family of human intracellular proteins involved in the detection of invasive bacteria and activation of the $\\ce{NF\\kappa B}$ transcription factor pathway.","notes":{"1":"In epithelial cells, NOD1 is essential for sensing intracellular Gram-negative bacteria through a tripeptide motif in the bacterial peptidoglycan."},"links":[{"term":"NFκB","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/13518"}],"sources":["PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1222 (https:\/\/doi.org\/10.1351\/PAC-REC-11-06-03)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/13519\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/13519\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/13519\/plain"},"citation":"Citation: 'nucleotide-binding oligomerization domain-containing protein 1, 2' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.13519","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-07-28T14:34:44+00:00"}}