metabolic activation

https://doi.org/10.1351/goldbook.13455
Formation of one or more chemically reactive intermediate(s) as a result of modification of a molecule by the xenobiotic-metabolizing enzymes of liver and other organs.
Notes:
  1. This may lead to acute cell damage and recognition of the damaged cell by the immune system as non-self.
  2. The reactive intermediate can also act as a hapten.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1212 [Terms] [Paper]
Citation: 'metabolic activation' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13455 RIS BibTex EndNote
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