{"term":{"id":"13294","title":"immunoglobulin gene superfamily","longtitle":"IUPAC Gold Book - immunoglobulin gene superfamily","doi":"10.1351\/goldbook.13294","code":"13294","status":"current","definitions":[{"id":1,"text":"Genes encoding proteins containing one or more immunoglobulin (Ig) domains (homology units) that are homologous to either Ig variable (V) region or constant (C) region domains. Cell surface and soluble molecules mediating recognition, adhesion, or binding functions in and outside the immune system, derived from the same precursor, belong to this family of molecules (e.g., immunoglobulin, T-cell receptor (TCR), major histocompatibility complex (MHC) class I and class II molecules, CD4, CD8, and $\\ce{Fc\\upgamma\\!R}$).","links":[{"term":"CD4","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/12973"},{"term":"CD8","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/12976"},{"term":"T-cell receptor (TCR)","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/13714"},{"term":"class II molecules","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/13432"},{"term":"constant (C) region","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/13039"},{"term":"domains","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/13099"},{"term":"immune system","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/13271"},{"term":"major histocompatibility complex (MHC) class I","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/13431"},{"term":"variable (V) region","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/13773"}],"sources":["PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1188 (https:\/\/doi.org\/10.1351\/PAC-REC-11-06-03)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/13294\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/13294\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/13294\/plain"},"citation":"Citation: 'immunoglobulin gene superfamily' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.13294","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-28T10:38:50+00:00"}}