humanized antibody

https://doi.org/10.1351/goldbook.13229
Genetically engineered monoclonal antibody of non-human origin in which all but the antigen-binding complementarity-determining region (CDR) sequences have been replaced with sequences derived from human antibodies.
Note: This procedure is carried out to minimize the immunogenicity of therapeutic, monoclonal antibodies.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1178 [Terms] [Paper]
Citation: 'humanized antibody' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13229 RIS BibTex EndNote
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