decay-accelerating factor

initialism: DAF
synonym: CD55
https://doi.org/10.1351/goldbook.13082
Cell-surface molecule that protects cells from lysis by complement.
Note: The decay-accelerating factor binds to C3 convertases of both the alternative pathway and classical pathway of complement activation and, by displacing Bb and C2b respectively, prevents their action. Its absence causes the disease paroxysmal nocturnal hemoglobinuria.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1155 [Terms] [Paper]
Citation: 'decay-accelerating factor' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13082 RIS BibTex EndNote
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