common variable immunodeficiency

https://doi.org/10.1351/goldbook.13027
Relatively common deficiency in antibody production, of unknown pathogenesis but strongly associated with genes mapping within the major histocompatibility complex (MHC).
Notes:
  1. Characterized by reduced γ globulin levels, generally affecting all the antibody classes, but sometimes only immunoglobulin G (IgG).
  2. Most patients have normal or near-normal numbers of B cells, which however do not differentiate into plasma cells.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1146 [Terms] [Paper]
Citation: 'common variable immunodeficiency' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13027 RIS BibTex EndNote
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