antimitochondrial antibody

initialism: AMA
https://doi.org/10.1351/goldbook.12895
Autoantibody producing a mitochondrial staining pattern on sections of various tissues and on tumor cell monolayers.
Note: According to the fluorescence pattern, different subtypes can be differentiated. Antimitochondrial antibodies of the subtype 2 (AMA-M2) are directed against antigens of three related 2-oxo acid dehydrogenase complexes (e.g., the E2 subunit of the pyruvate dehydrogenase complex, PDC-E2) localized to the inner mitochondrial membrane. AMA-M2 is a specific marker of primary biliary cirrhosis (PBC).
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1126 [Terms] [Paper]
Citation: 'antimitochondrial antibody' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12895 RIS BibTex EndNote
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