Title: antibody-dependent cellular cytotoxicity
Long Title: IUPAC Gold Book - antibody-dependent cellular cytotoxicity
DOI: 10.1351/goldbook.12879
Status: current

Definition
Cytotoxic reaction in which an antibody-coated target cell is directly killed by an Fc receptor-bearing leukocyte, e.g., NK cell, macrophage, neutrophil, or eosinophil.

Related Terms
- Cytotoxic: https://goldbook.iupac.org//terms/view/13071
- Fc receptor: https://goldbook.iupac.org//terms/view/13138
- NK cell: https://goldbook.iupac.org//terms/view/13499
- eosinophil: https://goldbook.iupac.org//terms/view/13117
- leukocyte: https://goldbook.iupac.org//terms/view/13379
- macrophage: https://goldbook.iupac.org//terms/view/13424
- neutrophil: https://goldbook.iupac.org//terms/view/13510
- target cell: https://goldbook.iupac.org//terms/view/13727

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1123 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/12879/html
- json: https://goldbook.iupac.org/terms/view/12879/json
- xml: https://goldbook.iupac.org/terms/view/12879/xml

Citation: Citation: 'antibody-dependent cellular cytotoxicity' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12879
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Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-04-18T00:19:18+00:00