12875 IUPAC Gold Book - anergy 10.1351/goldbook.12875 12875 current 1 Lack of an immune response, usually taken as lack of response to common recall antigens. The failure of B or T cells to proliferate in response to defined autoantigens (clonal anergy) is a primary mechanism of self-tolerance. B https://goldbook.iupac.org//terms/view/12932 T cells https://goldbook.iupac.org//terms/view/13724 autoantigens https://goldbook.iupac.org//terms/view/12914 clonal anergy https://goldbook.iupac.org//terms/view/13012 recall antigens https://goldbook.iupac.org//terms/view/13636 self-tolerance https://goldbook.iupac.org//terms/view/13669 PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1123 (https://doi.org/10.1351/PAC-REC-11-06-03) https://goldbook.iupac.org/terms/view/12875/html https://goldbook.iupac.org/terms/view/12875/json https://goldbook.iupac.org/terms/view/12875/plain Citation: 'anergy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12875 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-04-18T00:19:49+00:00