Title: anergy
Long Title: IUPAC Gold Book - anergy
DOI: 10.1351/goldbook.12875
Status: current

Definition
Lack of an immune response, usually taken as lack of response to common recall antigens.

Note
The failure of B or T cells to proliferate in response to defined autoantigens (clonal anergy) is a primary mechanism of self-tolerance.

Related Terms
- B: https://goldbook.iupac.org//terms/view/12932
- T cells: https://goldbook.iupac.org//terms/view/13724
- autoantigens: https://goldbook.iupac.org//terms/view/12914
- clonal anergy: https://goldbook.iupac.org//terms/view/13012
- recall antigens: https://goldbook.iupac.org//terms/view/13636
- self-tolerance: https://goldbook.iupac.org//terms/view/13669

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1123 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/12875/html
- json: https://goldbook.iupac.org/terms/view/12875/json
- xml: https://goldbook.iupac.org/terms/view/12875/xml

Citation: Citation: 'anergy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12875
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Accessed: 2026-04-18T00:18:52+00:00