phenotypic screening

https://doi.org/10.1351/goldbook.12712
Evaluation of compounds (small molecules, peptides, siRNA, etc.) in cells, tissues, or organisms for their ability to modify the system in a measurable manner.
Note: Phenotypic screening differs from target-based screens in that it assesses the overall response of the compound under investigation rather than its specific response on a purified molecular target. Advances in molecular biology resulted in a marked shift away from phenotypic screening, although the latter is now regaining popularity.
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1747 [Terms] [Paper]
Citation: 'phenotypic screening' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12712 RIS BibTex EndNote
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