noncompetitive antagonist

https://doi.org/10.1351/goldbook.12694
Functional antagonist that either binds irreversibly to a receptor or to a site distinct from that of the natural agonist.
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1743 [Terms] [Paper]