Title: neutral antagonist
Long Title: IUPAC Gold Book - neutral antagonist
DOI: 10.1351/goldbook.12691
Status: current

Definition
Ligand that blocks the responses of a receptor to both agonists and inverse agonists with the same intensity. It binds to the receptor without evoking any change of conformation or change to the ratio of activated to inactivated conformations.

Note
Perfect neutral antagonism is difficult to achieve.

Source
- PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1743 (https://doi.org/10.1351/PAC-REC-12-11-23)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/12691/html
- json: https://goldbook.iupac.org/terms/view/12691/json
- xml: https://goldbook.iupac.org/terms/view/12691/xml

Citation: Citation: 'neutral antagonist' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12691
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Accessed: 2026-07-14T12:28:50+00:00