Title: multidrug resistance
Long Title: IUPAC Gold Book - multidrug resistance
DOI: 10.1351/goldbook.12685
Status: current

Definition
Characteristic of cells that confers resistance to the effects of several different classes of drugs.

Note
There are several forms of drug resistance. Each is determined by genes that govern how cells will respond to chemical agents. One type of multidrug resistance involves the ability to eject several drugs out of cells (e.g., efflux pumps such as P-glycoprotein).

Related Terms
- P-glycoprotein: https://goldbook.iupac.org//terms/view/12704
- efflux pumps: https://goldbook.iupac.org//terms/view/12653

Source
- PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1742 (https://doi.org/10.1351/PAC-REC-12-11-23)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/12685/html
- json: https://goldbook.iupac.org/terms/view/12685/json
- xml: https://goldbook.iupac.org/terms/view/12685/xml

Citation: Citation: 'multidrug resistance' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12685
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Accessed: 2026-05-30T17:41:36+00:00