intrinsic solubility

https://doi.org/10.1351/goldbook.12672
Equilibrium solubility of the uncharged form of an ionisable compound at a pH where it is fully unionised. \[\ce{HA(s) <=> HA(aq)} \quad (1)\] \[\ce{HA(aq) <=> H^{+}(aq) + A^{-}(aq)} \quad (2)\]
Note: The intrinsic solubility can be determined from the analytical composition at a \(\pu{pH}\) where \([\ce{HA}]\) is very much greater than \([\ce{A^{-}}]\).
See also: equilibrium solubility, kinetic solubility, supersaturated solution
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1738 [Terms] [Paper]
Citation: 'intrinsic solubility' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12672 RIS BibTex EndNote
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