12616 IUPAC Gold Book - allosteric antagonist 10.1351/goldbook.12616 12616 current 1 Compound that binds to a receptor at a site separate from, but actively coupled to, that of the endogenous agonist to reduce actively receptor signals. The terms "allosteric antagonist" and "noncompetitive antagonist" are often synonymous but not necessarily so. noncompetitive antagonist https://goldbook.iupac.org//terms/view/12694 PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1726 (https://doi.org/10.1351/PAC-REC-12-11-23) https://goldbook.iupac.org/terms/view/12616/html https://goldbook.iupac.org/terms/view/12616/json https://goldbook.iupac.org/terms/view/12616/plain Citation: 'allosteric antagonist' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12616 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-05-09T11:01:55+00:00