{"term":{"id":"11936","title":"neuroinflammation","longtitle":"IUPAC Gold Book - neuroinflammation","doi":"10.1351\/goldbook.11936","code":"11936","status":"current","definitions":[{"id":1,"text":"Complex series of local immune responses within the nervous system to deal with a threat to the neural environment from infection, injury, or trauma.","notes":{"1":"In the brain, the process is initiated by microglial release of cytokines, often leading to increased blood–brain barrier permeability and a secondary lymphocyte-mediated inflammation."},"links":[{"term":"blood–brain barrier","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/11640"},{"term":"brain","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/11647"},{"term":"inflammation","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/11830"},{"term":"microglial","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/11872"},{"term":"nervous system","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/11916"}],"sources":["PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 888 (https:\/\/doi.org\/10.1515\/pac-2015-0103)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/11936\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/11936\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/11936\/plain"},"citation":"Citation: 'neuroinflammation' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.11936","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-07-16T03:30:00+00:00"}}