<?xml version="1.0" encoding="UTF-8"?>
<term>
  <id>11847</id>
  <title>lathyrism</title>
  <longtitle>IUPAC Gold Book - lathyrism</longtitle>
  <doi>10.1351/goldbook.11847</doi>
  <code>11847</code>
  <status>current</status>
  <synonym><em>synonym</em>: grass pea poisoning</synonym>
  <definitions>
    <item>
      <id>1</id>
      <text>Disease characterised by spastic paralysis of the legs and lower part of the body, pain, hyperesthesia, and paresthesia.</text>
      <notes>
        <item>Lathyrism is due to excessive ingestion of seeds of plants of the genus Lathyrus, which includes many kinds of pea, including Lathyrus sativa (grass pea). These seeds contain the glutamate analog and neurotoxicant oxalyldiaminopropionic acid (3-[(carboxycarbonyl)amino]alanine)).</item>
      </notes>
      <links>
        <item>
          <term>glutamate</term>
          <url>https://goldbook.iupac.org//terms/view/11792</url>
        </item>
        <item>
          <term>hyperesthesia</term>
          <url>https://goldbook.iupac.org//terms/view/11817</url>
        </item>
        <item>
          <term>neurotoxicant</term>
          <url>https://goldbook.iupac.org//terms/view/11949</url>
        </item>
        <item>
          <term>paralysis</term>
          <url>https://goldbook.iupac.org//terms/view/11989</url>
        </item>
        <item>
          <term>paresthesia</term>
          <url>https://goldbook.iupac.org//terms/view/11996</url>
        </item>
        <item>
          <term>spastic</term>
          <url>https://goldbook.iupac.org//terms/view/12082</url>
        </item>
      </links>
      <sources>
        <item>PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 877 (https://doi.org/10.1515/pac-2015-0103)</item>
      </sources>
    </item>
  </definitions>
  <altoutputs>
    <html>https://goldbook.iupac.org/terms/view/11847/html</html>
    <json>https://goldbook.iupac.org/terms/view/11847/json</json>
    <plain>https://goldbook.iupac.org/terms/view/11847/plain</plain>
  </altoutputs>
  <citation>Citation: 'lathyrism' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11847</citation>
  <license>The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.</license>
  <collection>If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .</collection>
  <disclaimer>The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.</disclaimer>
  <accessed>2026-07-13T05:10:42+00:00</accessed>
</term>
