The search for solutions to functions that provide a compromise between several desirable outcomes, such as potency, lack of toxicity, and good absorption, distribution, metabolism, and excretion (ADME) properties.
Source:
PAC, 2016, 88, 239. 'Glossary of terms used in computational drug design, part II (IUPAC Recommendations 2015)' on page 251 (https://doi.org/10.1515/pac-2012-1204)