The search for those combinations of properties that produces the best compromise between the various objectives of the search, for example properties of
compounds that are the best trade-off between potency, bioavailability, and selectivity.
See also: Pareto front, Pareto optimization
Source:
PAC, 2016, 88, 239. 'Glossary of terms used in computational drug design, part II (IUPAC Recommendations 2015)' on page 251 (https://doi.org/10.1515/pac-2012-1204)