A computational model designed to cover all of chemistry space although it typically includes a measure of if the molecule for which the properties are to be predicted is within or outside the applicability domain of the model.
Source: PAC, 2016, 88, 239. 'Glossary of terms used in computational drug design, part II (IUPAC Recommendations 2015)' on page 247 (https://doi.org/10.1515/pac-2012-1204)