Procedure in rodents wherein parents (P0 generation) and their offspring (F1 generation) are both exposed to a test substance and the second generation (F2) is examined for possible toxic effects.
See also: one-generation reprotox study
Source:
PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 816 (https://doi.org/10.1515/pac-2015-1202)