thalidomide

https://doi.org/10.1351/goldbook.11299

Teratogenic indole-based drug with sedative and anti-angiogenic properties.

Notes:
  1. The introduction of thalidomide for alleviating nausea in pregnancy in some countries in 1957 was soon linked to severe birth defects in the infant, with phocomelia being highly characteristic.
  2. Currently, it is used successfully to treat and prevent the moderate to severe skin lesions caused by leprosy, and is used together with dexamethasone to treat multiple myeloma.
Source:
PAC, 2016, 88, 713. (Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)) on page 812 [Terms] [Paper]
Citation: 'thalidomide' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.11299 RIS BibTex EndNote
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