somatic hypermutation

synonym: mutation (in immunology)
initialism: SHM
https://doi.org/10.1351/goldbook.11227
Programmed process of mutation affecting the variable (V) regions of immunoglobulin (Ig) genes. SHM affects only individual immune cells, and the mutations are not transmitted to offspring.
Notes:
  1. This process is part of the way the immune system adapts to new antigens.
  2. Mistargeted SMH is a likely mechanism in the development of B-cell lymphoma.
Source:
PAC, 2016, 88, 713. (Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)) on page 805 [Terms] [Paper]
Citation: 'somatic hypermutation' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.11227 RIS BibTex EndNote
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