Approach to elucidating the function of a gene by studying the effects on phenotype of expressed variations in a known DNA sequence.
Note: The term is intended to indicate the reverse of the approach (starting from a phenotype and working back to identify the gene) of
forward genetics.
Source:
PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 801 (https://doi.org/10.1515/pac-2015-1202)