Technique that studies patterns of heredity in high-risk families, in order to locate a disease-causing gene mutation by identifying co-inherited traits, usually by producing a LOD score.
Source: PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 773 (https://doi.org/10.1515/pac-2015-1202)