Synthetic nonsteroidal substance with estrogenic activity.
Notes: - DES was formerly given to reduce the risk of complications and loss of pregnancy but was shown to cause a rare vaginal tumor in female offspring who had been exposed to this drug in utero.
- DES also has effects on the reproductive organs of male progeny exposed in utero.
Source: PAC, 2016,
88, 713. (
Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)) on page 744 [
Terms] [
Paper]