10553 IUPAC Gold Book - congenital adrenal hyperplasia 10.1351/goldbook.10553 10553 current synonym: adrenogenital syndrome 1 Group of disorders caused by hyperplasia of the adrenal cortex or by malignant tumors, resulting in excess secretion of adrenocortical androgenic hormones, and characterized by masculinization of women, feminization of men, or precocious puberty in the male. The condition is associated with a decrease in the blood level of cortisol and an increase in the level of androgens in both sexes, most commonly as a result of 21-hydroxylase deficiency. 21-hydroxylase https://goldbook.iupac.org//terms/view/11260 adrenal https://goldbook.iupac.org//terms/view/10344 androgenic https://goldbook.iupac.org//terms/view/10385 androgens https://goldbook.iupac.org//terms/view/10384 feminization https://goldbook.iupac.org//terms/view/10709 hormones https://goldbook.iupac.org//terms/view/10810 hyperplasia https://goldbook.iupac.org//terms/view/10826 malignant https://goldbook.iupac.org//terms/view/10915 masculinization https://goldbook.iupac.org//terms/view/10918 puberty https://goldbook.iupac.org//terms/view/11152 tumors https://goldbook.iupac.org//terms/view/11330 PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 739 (https://doi.org/10.1515/pac-2015-1202) https://goldbook.iupac.org/terms/view/10553/html https://goldbook.iupac.org/terms/view/10553/json https://goldbook.iupac.org/terms/view/10553/plain Citation: 'congenital adrenal hyperplasia' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.10553 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-08-01T10:22:41+00:00