Procedure to evaluate both general systemic toxicity, with an emphasis on neurological endpoints, and notably reproductive effects and developmental progression in rodents. Groups of males and females are administered a test substance in graded doses prior to mating, during the mating period, and subsequently (up to two weeks post-mating in males and four days post-delivery in females).
Source:
PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 738 (https://doi.org/10.1515/pac-2015-1202)