<?xml version="1.0" encoding="UTF-8"?>
<term>
  <id>10438</id>
  <title>atrial-septal defect</title>
  <longtitle>IUPAC Gold Book - atrial-septal defect</longtitle>
  <doi>10.1351/goldbook.10438</doi>
  <code>10438</code>
  <status>current</status>
  <initialism><em>initialism</em>: ASD</initialism>
  <definitions>
    <item>
      <id>1</id>
      <text>Defect in the septum between the atria of the heart, due to failure of normal closure of the foramen ovale in the perinatal period.</text>
      <links>
        <item>
          <term>foramen ovale</term>
          <url>https://goldbook.iupac.org//terms/view/10737</url>
        </item>
        <item>
          <term>perinatal</term>
          <url>https://goldbook.iupac.org//terms/view/11079</url>
        </item>
      </links>
      <sources>
        <item>PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 728 (https://doi.org/10.1515/pac-2015-1202)</item>
      </sources>
    </item>
  </definitions>
  <altoutputs>
    <html>https://goldbook.iupac.org/terms/view/10438/html</html>
    <json>https://goldbook.iupac.org/terms/view/10438/json</json>
    <plain>https://goldbook.iupac.org/terms/view/10438/plain</plain>
  </altoutputs>
  <citation>Citation: 'atrial-septal defect' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.10438</citation>
  <license>The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.</license>
  <collection>If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .</collection>
  <disclaimer>The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.</disclaimer>
  <accessed>2026-07-14T03:02:51+00:00</accessed>
</term>
