Inherited disorder where ossification of cartilage is retarded, especially affecting growth of long bones, resulting in very short limbs and a comparatively large head. Type of dwarfism.
Note: Achondroplasia results from a mutation in the fibroblast growth factor receptor FGFR3 gene, increasing its activity in suppressing
endochondral ossification.
Source:
PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 715 (https://doi.org/10.1515/pac-2015-1202)