10276 IUPAC Gold Book - solid-phase microextraction 10.1351/goldbook.10276 10276 current initialisms: SPME, µSPE 1 Microextraction where the extraction phase is a solid. This term is often narrowly used to describe an extraction process employing a syringe-based sampling device with a short length of small gauge solid fiber or wire coated with sorbent attached to one end of the plunger of the syringe to facilitate bidirectional movement of the sorbent-coated fiber (wire) through the syringe needle for extraction, storage, and desorption of extractants. For extraction the sorbent is exposed to the headspace above the sample or immersed directly into the sample solution. Sample components diffuse into and/or onto the sorbent coating until equilibrium is reached. The extractants are subsequently recovered by thermal desorption into a gas stream (typically in the liner of an injection port of a gas chromatograph) or rinsed from the sorbent coating with solvent for determination by other methods. The extraction phase can also be a liquid physically coated on a fiber or wire support. Microextraction https://goldbook.iupac.org//terms/view/11552 extraction phase https://goldbook.iupac.org//terms/view/10175 sorbent https://goldbook.iupac.org//terms/view/10163 PAC, 2016, 88, 517. 'Glossary of terms used in extraction (IUPAC Recommendations 2016)' on page 548 (https://doi.org/10.1515/pac-2015-0903) https://goldbook.iupac.org/terms/view/10276/html https://goldbook.iupac.org/terms/view/10276/json https://goldbook.iupac.org/terms/view/10276/plain Citation: 'solid-phase microextraction' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.10276 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-06-29T08:33:04+00:00