Title: thermal field-flow fractionation
Long Title: IUPAC Gold Book - thermal field-flow fractionation
DOI: 10.1351/goldbook.09942
Status: current

Definition
Field-flow fractionation in which the physical force field is created by a temperature difference across the channel. 

Notes
1) One side of the channel is heated and the other side is cooled. A relatively small temperature difference between the top and bottom walls of the channel provides a high thermal gradient.
2) TFFF has been mainly used for the separation of lyophilic synthetic polymers, including ultrahigh molecular weight polymers and microgels. However, some reports of other types of macromolecules and particles, including aqueous solvents, are present in the literature.

Related Term
- Field-flow fractionation: https://goldbook.iupac.org//terms/view/09934

Source
- PAC, 2017, 90, 181. 'Terminology of separation methods (IUPAC Recommendations 2017)' on page 223 (https://doi.org/10.1515/pac-2017-0111)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/09942/html
- json: https://goldbook.iupac.org/terms/view/09942/json
- xml: https://goldbook.iupac.org/terms/view/09942/xml

Citation: Citation: 'thermal field-flow fractionation' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09942
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Accessed: 2026-07-26T15:21:04+00:00