09939 IUPAC Gold Book - split-flow thin-cell fractionation 10.1351/goldbook.09939 09939 current initialism: SPLITT 1 Separation in which laminar flow conditions are established between a liquid containing suspended sample and a carrier liquid, with a physical force field applied across the streams. Although SPILTT is similar to field-flow fractionation, it should not be referred to as FFF. The separation is achieved by the combined action of controlled flow rates and an applied cross-field. The system has two channel inlets and two outlets. Sample suspension is continuously pumped into one inlet and carrier liquid is pumped into the other inlet. Due to the laminar flow conditions, these two streams do not mix. SPLITT enables the separation of samples of masses of the order of grams. Fields that have been tested so far include gravitational, centrifugal and magnetic. A semi-preparative binary separation can be generated with smaller particles eluting from one outlet and larger particles emerging from the other. Careful manipulation of the inlet and outlet flow rates and the field strength enables the cut-off diameter of the particles to be selected. field-flow fractionation https://goldbook.iupac.org//terms/view/09934 PAC, 2017, 90, 181. 'Terminology of separation methods (IUPAC Recommendations 2017)' on page 222 (https://doi.org/10.1515/pac-2017-0111) https://goldbook.iupac.org/terms/view/09939/html https://goldbook.iupac.org/terms/view/09939/json https://goldbook.iupac.org/terms/view/09939/plain Citation: 'split-flow thin-cell fractionation' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09939 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-07-25T22:11:44+00:00