https://doi.org/10.1351/goldbook.09935
Field-flow fractionation in which the physical force field is a nonspecific hydrodynamic force field across the channel, generated by a secondary mobile phase cross-flow in addition to the normal channel flow.
Notes:
- The sample components are driven by the cross-flow toward the accumulation wall, which consists of porous frit covered with a permeable membrane.
- Like sedimentation field-flow fractionation (SdFFF), FlFFF can be used for submicron particles and macromolecules using the Brownian field-flow fractionation mode or micron size particles utilizing the hyperlayer mode.
- This technique can be applied to the size fractionation of different synthetic polymers, liposomes, proteins, viruses, dissolved organic matter, humic and fulvic acids as well as their complexes with trace metals, diesel soot particles, marine colloids, heterogeneous and arbitrarily shaped natural colloidal particles, gold colloid standards starting from 5 nm.