Binding of proteins to specific sites in deoxyribonucleic acid (DNA) based on the precise recognition of nucleotide sequence and/or conformation of the DNA.
Note: Sequence-specific DNA binding is typical for restriction enzymes, transcription factors and other proteins involved in cellular regulation, etc.
Source:
PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1186 (https://doi.org/10.1515/pac-2016-1120)