{"term":{"id":"09786","title":"top-down proteomics","longtitle":"IUPAC Gold Book - top-down proteomics","doi":"10.1351\/goldbook.09786","code":"09786","status":"current","definitions":[{"id":1,"text":"Approach to identify proteins and characterise their amino acid sequences or post-translational modifications either by direct mass spectrometric analysis of an ionised protein molecule or by sequential combination of protein\/peptide fragmentation in the ion source or mass analyser with ion trapping mass spectrometers.","links":[{"term":"bottom-up proteomics","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/09735"}],"sources":["PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1165 (https:\/\/doi.org\/10.1515\/pac-2016-1120)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/09786\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/09786\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/09786\/plain"},"citation":"Citation: 'top-down proteomics' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.09786","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-06-20T09:13:48+00:00"}}